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Common sites are the abdomen, outer thigh, and upper arm Sharps disposal: Dispose of used needles and pens in an FDA-cleared sharps container, not the household waste For a full injection technique walkthrough and site rotation schedule, see the retatrutide injection sites guide

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Timing and Composition A pattern that keeps showing up with new users is this: it’s not one isolated meal, but the combo of timing, portion, and composition that breaks tolerance: late-night high-fat dinners, sugary snacks without protein, or carb-heavy fast-food lunches tend to predict nausea or bloating the next day