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Patients should report persistent nausea, abdominal pain, rapid heart rate, or signs of thyroid dysfunction to their provider immediately
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Osteoarthritis The STEP 9 trial of 407 participants with a clinical and radiologic diagnosis of moderate knee osteoarthritis who had at least moderate pain and BMI ≥30 reported that semaglutide 2.4 mg weekly over 68 weeks improved the WOMAC pain score (range 0–100, with a higher score indicating more pain) by −41.7 points compared to −27.5 points with placebo (CI 95%
