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The enzyme-blocking effect from grapefruit persists for 24 hours or longer and is not time-dependent relative to medication timing

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a Key inclusion criteria for STEP 1, 3‐5 and 8 trials were age ≥18 years, BMI ≥30 kg/m 2 or ≥27 kg/m 2 with ≥1 weight‐related comorbidity (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease, history of at least one self‐reported unsuccessful dietary effort to lose weight and no type 1 or type 2 diabetes