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In the obesity trial (NCT04881760), eligible participants had a body mass index of 30 to 50 kg/m 2 or 27 to 1 mg, the dose was increased from a starting dose of 2 mg (slow escalation) or 4 mg (fast escalation) every 4 weeks for up to 12 weeks until the maximum dose was reached

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The growing use of these medications has prompted concerns regarding their ability to influence central nervous system (CNS) illness outcomes, including those of depression, excessive drug use and alcohol consumption, compulsive behaviors, and suicidal thoughts