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Semaglutide 2.4 mg (STEP 1 trial, N = 1,961, 68 weeks): Mean weight loss: 14.9% of baseline body weight Placebo-adjusted weight loss: 12.4% Patients losing ≥15% body weight: 50% Tirzepatide 15 mg (SURMOUNT-1 trial, N = 2,539, 72 weeks): Mean weight loss: 20.9% of baseline body weight Placebo-adjusted weight loss: 18.4% Patients losing ≥15% body weight: 63% Patients losing ≥20% body weight: 50% The difference is roughly 6 percentage points of total body weight, or about 12 to 15 pounds for a 200-pound patient over 72 weeks

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Users frequently ask about combining semaglutide with other weight loss agents