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Researchers studying semaglutide users have reported an observed association between these medications and optic nerve injuries, although ongoing research continues to evaluate causation, underlying risk factors, and the overall frequency of these events

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As GLP-1 Use Expands, Long-Term Safety Questions Remain Under Watch Danielle Valletti, Assistant Editor Kirsty Mackay Key Takeaways A FAERS liver-failure report for newly approved orforglipron underscores challenges separating true drug signals from background incidence, reporting bias, and confounding in early real-world pharmacovigilance