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Key risk factors include: History of pancreatitis – caution is advised in patients with previous pancreatitis Pre-existing gastrointestinal disease – particularly severe gastroparesis or severe GORD Gallbladder disease – rapid weight loss itself increases gallstone risk Concurrent medications – particularly NSAIDs, anticoagulants, or other drugs affecting gastric mucosa Helicobacter pylori infection – if present, may increase ulcer risk independently Diabetic gastroparesis – in patients with diabetes, pre-existing delayed gastric emptying may be exacerbated It should be noted that animal studies have shown an increased incidence of thyroid C-cell tumours with semaglutide, though the clinical relevance to humans is unknown
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