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Efficacy and safety of polyethylene glycol loxenatide monotherapy in type 2 diabetes patients: A multicentre, randomized, double-blind, placebo-controlled phase 3a clinical trial
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11 Elevated cortisol can negatively impact metabolism, promote fat storage (especially abdominal fat), disrupt other hormones involved in appetite regulation, increase cravings (particularly for high-sugar, high-fat foods), and contribute to insulin resistance, potentially hindering weight loss efforts despite medication and diet changes
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