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Can Ozempic Cause Constipation? The GLP-1 Gut Motility Paradox Explained
Use in Specific Populations Pregnancy: Advise females of potential risk to a fetus especially during the second and third trimesters Lactation: FARXIGA is not recommended when breastfeeding FARXIGA is indicated: as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and either established cardiovascular (CV) disease or multiple CV risk factors to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease at risk of progression FARXIGA is not recommended for use to improve glycemic control in patients with type 1 diabetes mellitus
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Most relevant to the GLP-1 conversation, a 2021 study in Nature Microbiology identified a protein secreted by Akkermansia, called P9, that stimulates GLP-1 release from intestinal L-cells by binding a receptor called ICAM-2 (Yoon et al., 2021)
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