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Indeed, Gcg activates the GLP-1R within localized concentrations in the double-digit picomolar (pM) range, while it more specifically activates the GcgR at concentrations 100 pM, however, the “normal” physiological range of endogenous glucagon concentrations in the HPV is contentious, having been argued to fall within 28–60 pM or 5–500 pM [152], [188]
