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Why Results Differ Semaglutide and dulaglutide differ in their molecular structure, affecting potency: Semaglutide: Modified structure for enhanced receptor binding Longer half-life and more stable blood levels Greater receptor activation at comparable doses Dulaglutide: Linked to IgG4 antibody fragment to extend half-life Effective but less potent than semaglutide Longer track record (approved earlier) These structural differences explain why semaglutide produces greater effects despite both being weekly GLP-1 medications