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There's been a lot of discussion about GLP-1 medications and the gallbladder. At first, concerns were raised about increased risk. But newer insights suggest the relationship is more complex than we thought.

For the behavioral experiment of SPF mice injected Ex-4 and ABX mice injected Ex(9- 39), mice were tested for OFT at 10 weeks of age, EPM at 11 weeks of age, and novel object recognition test at 12 weeks of age

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Increasing energy supply suppressed proglucagon expression in GF mice, suggesting that colonic L cells sense energy availability and regulate basal GLP-1 secretion accordingly