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Recent work demonstrated that sEVs loaded with semaglutide or tirzepatide crossed the gut barrier intact and produced significant 4-hour post-prandial glucose reductions in mice without inducing detectable anti-drug antibodies, underscoring their innate immune stealth [174]

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doi: 10.1016/S0140-6736(10)61080-X 113 NogueirasRVeyrat-DurebexCSuchanekPMKleinMTschöpJCaldwellCet al