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The "Last 20%" thesis of this report is that the marginal clinical territory between the first 15% of weight loss (where semaglutide operates) and the next 10-15% (where Retatrutide and the triple class operate) is precisely the zone where real-world adherence, tolerability, and dose-titration patterns determine how much of the trial number actually reaches patients
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![PDF] Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide](https://figures.semanticscholar.org/594349790d0e9a09f8b5843f2782af9cfaaa7bf4/37-Figure3-1.png)
