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Gastrointestinal side effects are a common issue with both medications individually

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In mice, GLP-2 promoted the growth of the small intestine and large intestine, and inconsistently, the combination of GLP-2 and high-dose GLP-2 (3-33) reduces the growth-promoting effect, speculating that it may be due to competitive antagonism between GLP-2 and GLP-2 (3-33) (Thulesen et al., 2002)