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Last Published 05.01.2026 Effective Date: 05.01.2026 – This policy addresses the use of Crysvita® (burosumab-twza) for the treatment of X-linked hypophosphatemia (XLH) and Fibroblast Growth Factor 23 (FGF23)-related hypophosphatemia in tumor-induced osteomalacia (TIO)
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The classic precedent is captopril, the first ACE inhibitor for hypertension, developed from Brazilian pit viper ( Bothrops jararaca ) venom
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