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Implications for employers: - This demonstrates that two of the GLP-1 drugs (tirzepatide and semaglutide, both injectable) are associated with much more weight loss than even especially effective diets

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The molecular mechanisms underlying the neuroprotective effects of central GLP-1R agonism are, at least in part, mediated through the ability to increase cAMP formation and subsequently to enhance activation of PI3-kinase and ERK