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Start your intake → What the triple-agonist mechanism is — and how it differs from dual agonists Retatrutide activates three receptors at once: GLP-1 (appetite suppression and insulin response), GIP (insulin response and adipose handling, the receptor tirzepatide adds on top of GLP-1), and glucagon (energy expenditure and hepatic fat metabolism)
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Plasma half-life is about 159-195 hours, or roughly 6.6-8.1 days