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[DOI] [PubMed] [Google Scholar] [32].Singh P, Muhammad I.j., Nelson NE, Tran KTM, Vinikoor T, Chorsi MT, D’Orio E, Nguyen TD, Transdermal delivery for gene therapy, Drug Delivery and Translational Research 12(11) (2022) 2613–2633
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They discovered that GLP-1: Was secreted by L-cells in the small intestine in response to food Stimulated insulin secretion only when blood glucose was elevated Suppressed glucagon release Slowed gastric emptying Reduced appetite in animal models The problem was that native GLP-1 had a half-life of about two minutes in the human body
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