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And in the brain, it crosses the blood-brain barrier and activates anorexigenic neurons in the hypothalamus, specifically the POMC/CART pathways that signal fullness while suppressing the NPY/AgRP pathways that drive hunger

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The mean (SD) age of the patient population was 58.2 years (11.0) ( Table 1 ) with a median of 58.0 (not shown)