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glp 1 and mental health Psychological behavioral effects of GLP-1 and GIP agonists in weight loss: a comprehensive review | Journal of Diabetes & ...

Particularly, the reduction of GLP-1 release over time has been an observed feature of T2DM development, as GLP-1 reduces glucagon secretion and hepatic gluconeogenesis while promoting insulin secretion, thereby effectively minimizing hyperglycemia [106]

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Clinical studies and real-world evidence consistently showed that higher doses of drugs like Semaglutide and Tirzepatide led to greater reductions in body weight, which drove higher demand among both patients and prescribers