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Additional uncertainty comes from the possibility of new therapies or weight-management innovations entering the market, as well as the potential for longer-term side effects that have not yet emerged in real-world populations
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For these reasons, the current view of depression as an exclusively neurological disorder was expanded to consider it a systemic disease, given that depression involves the impairment of the hypothalamic−pituitary−adrenal (HPA) axis, immune dysregulation, and disturbance of the gut-brain axis (Maes et al., 2011
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