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HBx can influence the activity of metabolic transcription factors, such as sterol regulatory element-binding proteins (SREBPs), which are key regulators of de novo lipogenesis ( Thus, for viral etiologies, the virus acts as the initial trigger, but the resulting metabolic dysregulation and chronic inflammatory state which overlaps significantly with the pathophysiology of MASLD are focused on and ultimately destroy the liver’s tissue architecture, creating the sustained carcinogenic environment (Wang and Zhang, 2023
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